The BWH Metabolic Core comprises a 24 cage Comprehensive Lab Animal Monitoring System (CLAMS) that collects quantitative 24-hour monitoring data to assess multiple metabolic and physiologic parameters in mice. Our core is specialized, allowing for the precise control of ambient temperature ranging from thermoneutrality (30°C) to cold (4°C) for study of environmental changes.
We also accommodate exercise research providing individual exercise wheels for acute and sustained exercise. The capabilities of our system include measurement of physiological (e.g., oxygen consumption, carbon dioxide production, energy expenditure, and body temperature) and behavioral (e.g. feeding, sleeping, locomotion, and running wheel activity) parameters measured in up to 24 mice at one time.
The core provides help in experimental design, data analysis, and scientific interpretation. We also provide, assessment of energy consumption versus absorption (fecal bomb calorimetry), fecal lipid content, and glucose and insulin tolerance testing.
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